hrp0084p2-445 | Gonads | ESPE2015

The Late Effects after the Haematopoietic Stem Cells Transplantation for Patients with Non-Neoplastic Disease

Sutani Akito , Miyakawa Yuichi , Tsuji Atsumi , Aoki Yuki , Takasawa Kei , Takagi Masatoshi , Imai Kohsuke , Kashimada Kenichi , Morio Tomohiro

Background: As a curative therapy, haematopoietic stem cells transplantation (HSCT) has been also used for patients with non-neoplastic diseases such as aplastic anemia, primary immunodeficiency, and some congenital metabolic diseases. For these diseases, the intensity of the conditioning has been reduced comparing to that of malignancy diseases. Therefore, late effects of HSCT for non-neoplastic diseases has been expected to be milder than that for neoplastic diseases, howeve...

hrp0084p2-282 | Diabetes | ESPE2015

Total-Body Irradiation is a Major Risk Factor for Young Adult Onset Diabetes Mellitus and Hyperlipidemia in Childhood Cancer Survivors after Hematopoietic Stem Cell Transplantation

Nakagawa Ryuichi , Tsuji Atsumi , Aoki Yuki , Nakajima Keisuke , Sutani Akito , Miyakawa Yuichi , Takasawa Kei , Tomizawa Daisuke , Takagi Masatoshi , Kashimada Kenichi , Morio Tomohiro

Background: Haematopoietic stem cell transplantation (HSCT) is a risk factor for young adult onset diabetes mellitus (DM) and hyperlipidaemia (HL) as late effects, especially the use of total-body irradiation (TBI). In order to investigate the clinical details, we retrospectively analysed the post-HSCT patients in our institution that required treatment for DM and/or HL.Results: From 1983 to 2012, 24 children received HSCT in our hospital because of haem...